The Mohawk homeobox gene is a critical regulator of tendon differentiation.
Proc Natl Acad Sci U S A
; 107(23): 10538-42, 2010 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-20498044
ABSTRACT
Mohawk (Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.
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Base de dados:
MEDLINE
Assunto principal:
Tendões
/
Diferenciação Celular
/
Proteínas de Homeodomínio
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Regulação da Expressão Gênica no Desenvolvimento
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article