High-dose vs low-dose proton pump inhibitors for upper gastrointestinal bleeding: a meta-analysis.
World J Gastroenterol
; 16(20): 2558-65, 2010 May 28.
Article
em En
| MEDLINE
| ID: mdl-20503458
ABSTRACT
AIM:
To evaluate the efficacy of high-dose proton pump inhibitors (PPIs) vs low-dose PPIs for patients with upper gastrointestinal bleeding.METHODS:
PubMed, Embase, the Cochrane Library, and Web of Science were searched to identify relevant randomized controlled trials (RCTs). Eligible trials were RCTs that compared high-dose PPI with low-dose PPI following endoscopic hemostasis. The primary endpoint was rebleeding; secondary endpoints were patient numbers that needed surgery, and mortality. The meta-analysis was performed with a fixed effects model or random effects model.RESULTS:
Nine eligible RCTs including 1342 patients were retrieved. The results showed that high-dose intravenous PPI was not superior to low-dose intravenous PPI in reducing rebleeding [odds ratio (OR) = 1.091, 95% confidential interval (CI) 0.777-1.532], need for surgery (OR = 1.522, 95% CI 0.643-3.605) and mortality (OR = 1.022, 95% CI 0.476-2.196). Subgroup analysis according to different region revealed no difference in rebleeding rate between Asian patients (OR = 0.831, 95% CI, 0.467-1.480) and European patients (OR = 1.263, 95% CI 0.827-1.929).CONCLUSION:
Low-dose intravenous PPI can achieve the same efficacy as high-dose PPI following endoscopic hemostasis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trato Gastrointestinal Superior
/
Inibidores da Bomba de Prótons
/
Hemorragia Gastrointestinal
Tipo de estudo:
Clinical_trials
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article