Calponin expression in laryngeal myoepithelial carcinoma and its prognostic implications: a case report and literature review.
J Int Med Res
; 38(2): 711-9, 2010.
Article
em En
| MEDLINE
| ID: mdl-20515587
ABSTRACT
A case report of laryngeal myoepithelial carcinoma (MEC) is presented and the literature concerning prognostic factors in MEC is reviewed. A 61-year old man was admitted to hospital with hoarseness and progressive dyspnoea. On examination, both vocal cords were fixed in the midline with a glottic fissure of only 3 mm. No tumour was seen, but the subglottis was not completely visible. A computed tomography scan showed a soft mass below the right vocal cord obstructing two-thirds of the larynx. On suspension laryngoscopy, a dull mass (1.5 x 1.5 cm) was seen below the right vocal cord, which was malignant on frozen biopsy. A total laryngectomy was performed and the patient received radiotherapy. He died of recurrence 25 months later. The tumour was positive for cytokeratin 14, S-100 protein and calponin. MEC of the larynx is extremely rare. The clinical behaviour of MEC is variable and prognostic factors have been poorly analysed. Calponin expression may be a prognostic factor, but other factors also affect the outcome in MEC.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ligação ao Cálcio
/
Biomarcadores Tumorais
/
Neoplasias Laríngeas
/
Mioepitelioma
/
Proteínas dos Microfilamentos
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article