Association of SUMO4 M55V polymorphism with susceptibility to autoimmune and inflammatory diseases: a meta-analysis.

ABSTRACT

The purpose of this study was to generate large-scale evidence on whether SUMO4 M55V polymorphism is associated with autoimmune and inflammatory diseases using a meta-analysis. We surveyed studies on the association of SUMO4 M55V polymorphism with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed for genotypes AG versus AA, GG versus AA, GG versus AA + AG, AG + GG versus AA and G allele versus A allele in a fixed/random effect model. We identified 16 studies (11, 407 cases and 10, 679 controls) using PubMed search. When all groups were pooled, we detected the association of SUMO4 M55V polymorphism with autoimmune and inflammatory diseases (G versus A OR = 1.11, 95%CI = 1.03-1.19, P = 0.005; AG +GG versus AA OR=1.17, 95%CI=1.06-1.28, P=0.001; GG versus AA+AG OR=1.07, 95%CI=0.94-1.21, P=0.29; GG versus AA OR=1.15, 95%CI=1.00-1.34, P=0.06; AG versus AA OR=1.15, 95%CI=1.08-1.23, P<0.0001). In subgroup analyses, we detected the association of SUMO4 M55V polymorphism with autoimmune and inflammatory diseases in Asian population (G versus A OR=1.18, 95%CI=1.08-1.28, P=0.0001; AG+GG versus AA OR=1.30, 95%CI=1.16-1.45, P<0.00001; GG versus AA+AG OR=1.04, 95%CI=0.78-1.37, P=0.80; GG versus AA OR=1.20, 95%CI=0.99-1.45, P=0.07; AG versus AA OR=1.32, 95%CI=1.18-1.49, P<0.00001). But the association was not found in Caucasian population. Meanwhile, an association of SUMO4 M55V polymorphism with autoimmune diabetes was found (G versus A OR=1.18, 95%CI=1.08-1.30, P=0.0005; AG+GG versus AA OR=1.22, 95%CI=1.13-1.32, P<0.00001; GG versus AA+AG OR=1.15, 95%CI=0.96-1.38, P=0.13; GG versus AA OR=1.32, 95%CI=1.08-1.60, P=0.006; AG versus AA OR=1.23, 95%CI=1.13-1.33, P<0.00001). This meta-analysis demonstrates the association of SUMO4 M55V polymorphism with autoimmune and inflammatory diseases, especially in Asian population.