Endotoxin activity level and septic shock: a possible role for specific anti-endotoxin therapy?
Contrib Nephrol
; 167: 102-110, 2010.
Article
em En
| MEDLINE
| ID: mdl-20519904
ABSTRACT
Endotoxin activity (EA) plays an essential role in sepsis syndrome pathogenesis. There has been considerable interest in measuring and removing EA to predict and improve the morbidity and mortality of patients with sepsis. We performed a prospective study to assess the prevalence of EA in critically ill patients and its association with organ dysfunction and outcome, as well as in septic shock. EA (EAA(TM)) was measured within 24 h from onset of refractory septic shock in an intensive care unit. Our study demonstrated that EA level is independent from the type or the source of infection, but reflects the severity of illness in critically ill septic shock patients. Extracorporeal EA removal (PMX-HP) was assessed following our ICU clinical practice. PMX-HP seems to have better outcome, but further studies are required to verify this hypothesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Choque Séptico
/
Infecções por Bactérias Gram-Negativas
/
Sepse
/
Endotoxinas
/
Circulação Extracorpórea
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article