Antigen-presenting cells in pregnant and non-pregnant human myometrium.
Am J Reprod Immunol
; 64(3): 188-96, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20528834
ABSTRACT
PROBLEM:
Inflammatory cells play a crucial role in human parturition. Different populations of leucocytes invade the reproductive tract. Numerous studies have described the decidual immune cell population in pregnant and non-pregnant endometrium. However, little is known about the presence of immune cells in human myometrium. METHOD OF STUDY we herein analysed a spectrum of immune cells in human myometrium comparing tissue samples from non-pregnant (n = 8) and pregnant (n = 10) uteri. Applying immunohistochemistry with a panel of antibodies specific for T cells, monocytes, natural killer cells, B cells and antigen-presenting cells (CD4, CD8, CD14, CD15, CD16, CD19, CD56, CD68, CD83, HLA-DR, DC-Sign, mast cell tryptase), we characterized the immune cell population of human myometrium.RESULTS:
a significantly higher number of CD14, CD15, CD16, DC-SIGN as well as CD4-positive cells were found in myometrium of pregnant compared to non-pregnant uteri, while mast cells were significantly reduced in pregnant myometrium.CONCLUSION:
all markers found increased in pregnant myometrium indicate monocyte/macrophage lineage cells and thus suggest a possible involvement of these cells in healthy pregnancy maintenance. Monocytes/macrophages might produce a microenvironment that permits a controlled invasion of trophoblast cells into the myometrium while preventing a rejection of the semiallogenic conceptus and providing an important barrier against invading pathogenes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Macrófagos
/
Mastócitos
/
Miométrio
/
Células Apresentadoras de Antígenos
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article