The structural requirements of matriptase in its ectodomain release in polarized epithelial cells.
Biosci Biotechnol Biochem
; 74(6): 1295-7, 2010.
Article
em En
| MEDLINE
| ID: mdl-20530886
ABSTRACT
Matriptase is a type-II transmembrane serine protease abundantly expressed in polarized epithelia. The ectodomain of matriptase is released from the cell surface. In the present study, we found that the post-translational cleavage between Gly149 and Ser150 and the existence of catalytic domain are critical for the ectodomain release of matriptase in stable transfection experiments using the polarized Madin-Darby canine kidney epithelial cell line.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Serina Endopeptidases
/
Polaridade Celular
/
Células Epiteliais
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article