Synthesis and antileishmanial activity of some 1- or 2-(dihydroxyalkyl) and 3-(dihydroxyalkoxy)pyrazolo [3,4-d] pyrimidines.
Farmaco
; 46(1): 75-84, 1991 Jan.
Article
em En
| MEDLINE
| ID: mdl-2054043
ABSTRACT
Several new derivatives of 4-amino-, 4,6-diamino- and 4-hydrazino-[3,4-d]pyrimidine dihydroxyalkyl substituted in the 1 or 2 positions, or dihydroxyalkoxy substituted in the 3 position have been synthesized. Some of these compounds were evaluated for their activity against Leishmania infantum in mice. The highest degree of antileishmanial activity was displayed by the 4-amino-1-(dihydroxyalkyl) derivatives which yielded parasite inhibition values nearly comparable with that of glucantime in a standard 5-day test.
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Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Pirimidinas
/
Leishmania donovani
/
Leishmaniose Visceral
/
Antiprotozoários
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article