Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development.
Nat Immunol
; 11(7): 585-93, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20543838
ABSTRACT
The classical model of hematopoiesis posits the segregation of lymphoid and myeloid lineages as the earliest fate decision. The validity of this model in the mouse has been questioned; however, little is known about the lineage potential of human progenitors. Here we provide a comprehensive analysis of the human hematopoietic hierarchy by clonally mapping the developmental potential of seven progenitor classes from neonatal cord blood and adult bone marrow. Human multilymphoid progenitors, identified as a distinct population of Thy-1(neg-lo)CD45RA(+) cells in the CD34(+)CD38(-) stem cell compartment, gave rise to all lymphoid cell types, as well as monocytes, macrophages and dendritic cells, which indicated that these myeloid lineages arise in early lymphoid lineage specification. Thus, as in the mouse, human hematopoiesis does not follow a rigid model of myeloid-lymphoid segregation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
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Antígenos CD
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Linhagem da Célula
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Sangue Fetal
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Hematopoese
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Macrófagos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Animals
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Humans
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Newborn
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article