Characterization of skeletal muscle effects associated with daptomycin in rats.
Muscle Nerve
; 42(3): 385-93, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20544940
ABSTRACT
Daptomycin is a lipopeptide antibiotic with strong bactericidal effects against Gram-positive bacteria and minor side effects on skeletal muscles. The type and magnitude of the early effect of daptomycin on skeletal muscles of rats was quantified by histopathology, examination of contractile properties, Evans Blue Dye uptake, and effect on the patch repair process. A single dose of daptomycin of up to 200 mg/kg had no effect on muscle fibers. A dose of 150 mg/kg of daptomycin, twice per day for 3 days, produced a small number of myofibers (
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Daptomicina
/
Músculo Esquelético
/
Antibacterianos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article