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In vivo anti-angiogenic effects further support the promise of the antineoplasic activity of methyl jasmonate.
Pereira Lopes, J E F; Barbosa, M R; Stella, C N; Santos, W A; Pereira, E M; Nogueira-Neto, J; Augusto, E M; Silva, L V; Smaili, S S; Gomes, L F.
Afiliação
  • Pereira Lopes JE; Departamento de Análises Clínicas e Toxicológicas, Universidade de São Paulo, SP, Brazil.
Braz J Biol ; 70(2): 443-9, 2010 May.
Article em En | MEDLINE | ID: mdl-20549071
Molecular plant components have long been aimed at the angiogenesis and anti-angiogenesis pathways, and have been tested as sources for antineoplasic drugs with promising success. The present work deals with the anti-angiogenic effects of Methyl Jasmonate. Jasmonate derivatives were demonstrated to selectively damage the mitochondria of cancer cells. In vitro, 1-10 mM Methyl Jasmonate induced the cell death of the human umbilical vein endothelial cells (HUVEC) and the Murine melanoma cells (B16F10), while micromolar concentrations were ineffective. In vivo, comparable concentrations were toxic and reduced the vessel density of the Chorioallantoic Membrane of the Chicken Embryo (CAM). However, 1-10 microM concentrations produced a complex effect. There was increased capillary budding, but the new vessels were leakier and less organised than corresponding controls. It is suggested that not only direct toxicity, but also the drug effects upon angiogenesis are relevant to the antineoplasic effects of Methyl Jasmonate.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Angiogênese / Ciclopentanos / Células Endoteliais / Membrana Corioalantoide / Oxilipinas / Acetatos / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Angiogênese / Ciclopentanos / Células Endoteliais / Membrana Corioalantoide / Oxilipinas / Acetatos / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article