Pushing and pulling in prokaryotic DNA segregation.
Cell
; 141(6): 927-42, 2010 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-20550930
ABSTRACT
In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The best-understood type of partitioning (par) locus encodes an actin homolog called ParM, which forms dynamically unstable filaments that push plasmids apart in a process reminiscent of mitosis. However, the most common type of par locus, which is present on many plasmids and most bacterial chromosomes, encodes a P loop ATPase (ParA) that distributes plasmids equidistant from one another on the bacterial nucleoid. A third type of par locus encodes a tubulin homolog (TubZ) that forms cytoskeletal filaments that move rapidly with treadmill dynamics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
DNA Bacteriano
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article