Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment.
Proc Jpn Acad Ser B Phys Biol Sci
; 86(6): 563-77, 2010.
Article
em En
| MEDLINE
| ID: mdl-20551594
ABSTRACT
Pancreatic beta-cells play a central role in the maintenance glucose homeostasis by secreting insulin, a key hormone that regulates blood glucose levels. Dysfunction of the beta-cells and/or a decrease in the beta-cell mass are associated closely with the pathogenesis and pathophysiology of diabetes mellitus, a major metabolic disease that is rapidly increasing worldwide. Clarification of the mechanisms of insulin secretion and beta-cell fate provides a basis for the understanding of diabetes and its better treatment. In this review, we discuss cell signaling critical for the insulin secretory function based on our recent studies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Diabetes Mellitus
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Células Secretoras de Insulina
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article