Your browser doesn't support javascript.
loading
Up-front temozolomide in elderly patients with anaplastic oligodendroglioma and oligoastrocytoma.
Ducray, François; del Rio, Monica Sierra; Carpentier, Catherine; Psimaras, Dimitri; Idbaih, Ahmed; Dehais, Caroline; Kaloshi, Gentian; Mokhtari, Karima; Taillibert, Sophie; Laigle-Donadey, Florence; Omuro, Antonio; Sanson, Marc; Delattre, Jean-Yves; Hoang-Xuan, Khê.
Afiliação
  • Ducray F; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie Mazarin, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013, Paris, France.
J Neurooncol ; 101(3): 457-62, 2011 Feb.
Article em En | MEDLINE | ID: mdl-20556480
Optimal treatment of anaplastic oligodendroglial tumors (AOT) in elderly patients is debatable. We report a retrospective study of 44 consecutive patients aged 70 years or older [median age: 74 years; median Karnofsky performance status (KPS): 70] treated with up-front chemotherapy using temozolomide (TMZ) at conventional doses until tumor progression. O(6)-methylguanine-DNA methyltransferase promoter (MGMTP) methylation was assessed in 38 patients. Of the 41 evaluable patients, partial response (PR) was seen in 13 (32%) patients, 17 (41%) patients achieved stable disease, while the disease progressed in 11 (27%) patients. Median progression-free survival (PFS) and overall survival (OS) were 6.9 and 12.4 months, respectively. Hematotoxicity grades 3-4 occurred in nine patients (20%). MGMTP was methylated in 50% of patients and was associated with both longer PFS (8.7 versus 5.7 months, P = 0.01) and longer OS (16.1 versus 12.4 months, P = 0.05). The rate of responders to chemotherapy was similar in MGMTP-methylated (38%) and in MGMTP-unmethylated patients (31%), but duration of response was significantly longer in responders with methylated MGMTP than in responders with unmethylated MGMTP (16.1 versus 9.6 months, P = 0.0004). This study demonstrates that a substantial number of elderly patients with AOT can achieve prolonged survival with up-front chemotherapy using TMZ. Further investigation is needed to determine whether this treatment is preferable to initial radiation therapy.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligodendroglioma / Neoplasias Encefálicas / Antineoplásicos Alquilantes / Metilação de DNA / Dacarbazina Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligodendroglioma / Neoplasias Encefálicas / Antineoplásicos Alquilantes / Metilação de DNA / Dacarbazina Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2011 Tipo de documento: Article