7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata.
Bioorg Med Chem Lett
; 20(14): 4057-9, 2010 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-20558060
ABSTRACT
Mass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pironas
/
Tripanossomicidas
/
Lactonas
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article