Development of the spatial representation system in the rat.
Science
; 328(5985): 1576-80, 2010 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-20558721
ABSTRACT
In the adult brain, space and orientation are represented by an elaborate hippocampal-parahippocampal circuit consisting of head-direction cells, place cells, and grid cells. We report that a rudimentary map of space is already present when 2 1/2-week-old rat pups explore an open environment outside the nest for the first time. Head-direction cells in the pre- and parasubiculum have adultlike properties from the beginning. Place and grid cells are also present but evolve more gradually. Grid cells show the slowest development. The gradual refinement of the spatial representation is accompanied by an increase in network synchrony among entorhinal stellate cells. The presence of adultlike directional signals at the onset of navigation raises the possibility that such signals are instrumental in setting up networks for place and grid representation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Percepção Espacial
/
Comportamento Espacial
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Córtex Entorrinal
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Giro Para-Hipocampal
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Região CA1 Hipocampal
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Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article