Just when you thought it was safe to go into the membrane: the growing complexities of extra-nuclear progesterone signaling.
Breast Cancer Res
; 12(3): 109, 2010.
Article
em En
| MEDLINE
| ID: mdl-20561377
ABSTRACT
The diversity of membrane-initiated progesterone actions has made characterization and establishment of its biological importance a complicated endeavor. A new study by Zuo and colleagues shows that progesterone via endogenous membrane progesterone receptor-alpha acts as a negative regulator of proliferation and epithelial to mesenchymal transition in a breast cancer cell line. These progesterone-mediated actions appear to be regulated through epidermal growth factor receptor and phosphatidylinositol 3-kinase signaling localized in caveolae. Moreover, the study shows expression of membrane progesterone receptor-alpha in benign and malignant breast cancer tissues. These data bring forth novel concepts with regard to progesterone actions in the breast; however, further work is warranted to fully characterize the physiologic actions of extra-nuclear progesterone signaling in the breast.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Progesterona
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Neoplasias da Mama
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Transdução de Sinais
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Receptores de Progesterona
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Membrana Celular
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Mesoderma
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article