Pathophysiology of septic encephalopathy--an unsolved puzzle.
Crit Care
; 14(3): 165, 2010.
Article
em En
| MEDLINE
| ID: mdl-20565858
ABSTRACT
The exact cellular and molecular mechanisms of sepsis-induced encephalopathy remain elusive. The breakdown of the blood-brain barrier (BBB) is considered a focal point in the development of sepsis-induced brain damage. Contributing factors for the compromise of the BBB include cytokines and chemokines, activation of the complement cascade, phagocyte-derived toxic mediators, and bacterial products. To date, we are far from fully understanding the neuropathology that develops as a secondary remote organ injury as a consequence of sepsis. However, recent studies suggest that bacterial proteins may readily cross the functional BBB and trigger an inflammatory response in the subarachnoid space, in absence of a bacterial invasion. A better understanding of the pathophysiological events leading to septic encephalopathy appears crucial to advance the clinical care for this vulnerable patient population.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Barreira Hematoencefálica
/
Sepse
/
Infecções Bacterianas do Sistema Nervoso Central
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Hipóxia-Isquemia Encefálica
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article