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Digital gangrene associated with anticentromere antibodies: a case report.
Bolster, Lauren; Taylor-Gjevre, Regina M; Nair, Bindu; Gjevre, John A.
Afiliação
  • Bolster L; Division of Rheumatology, Department of Internal Medicine, University of Saskatchewan, Saskatoon, SK, Canada. r.gjevre@usask.ca.
J Med Case Rep ; 4: 189, 2010 Jun 22.
Article em En | MEDLINE | ID: mdl-20569489
INTRODUCTION: Anticentromere antibodies have been associated with peripheral vascular occlusive disease, most frequently accompanied by sclerodactyly in the context of a connective tissue disorder. We report a case of digital gangrene with no other clinical associations except positive anticentromere antibodies. CASE PRESENTATION: Our patient, a 53-year-old Caucasian woman, non-smoker, presented with progressive pain and blackening of the distal right third finger over the preceding five weeks. No sclerodactyly was evident. She was anticentromere antibody positive at greater than 100 U/mL. Angiography revealed diffuse distal vasculopathy in both upper extremities. Other investigations were unremarkable. CONCLUSIONS: It is rare for anticentromere antibody-associated digital necrosis to develop without concomitant sclerodactyly. However, this patient's case illustrates the need to consider an autoimmune contribution to the pathogenesis of digital ischemia even in the absence of a recognizable connective tissue disease.

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2010 Tipo de documento: Article