BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Bioorg Med Chem Lett
; 20(15): 4639-44, 2010 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-20579874
ABSTRACT
Inhibition of the aspartyl protease BACE-1 has the potential to deliver a disease-modifying therapy for Alzheimer's disease. Herein, is described a series of potent inhibitors based on an hydroxyethylamine (HEA) transition state mimetic template. These inhibitors interact with the non prime side of the enzyme using a novel edge-to-face interaction with Arg-296.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Inibidores de Proteases
/
Etilaminas
/
Secretases da Proteína Precursora do Amiloide
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article