Peptide HIV-1 integrase inhibitors from HIV-1 gene products.
J Med Chem
; 53(14): 5356-60, 2010 Jul 22.
Article
em En
| MEDLINE
| ID: mdl-20586421
ABSTRACT
Anti-HIV peptides with inhibitory activity against HIV-1 integrase (IN) have been found in overlapping peptide libraries derived from HIV-1 gene products. In a strand transfer assay using IN, inhibitory active peptides with certain sequential motifs related to Vpr- and Env-derived peptides were found. The addition of an octa-arginyl group to the inhibitory peptides caused a remarkable inhibition of the strand transfer and 3'-end-processing reactions catalyzed by IN and significant inhibition against HIV replication.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
HIV-1
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Inibidores de Integrase de HIV
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Biblioteca de Peptídeos
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Produtos do Gene env do Vírus da Imunodeficiência Humana
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Proteínas do Vírus da Imunodeficiência Humana
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Produtos do Gene vpr do Vírus da Imunodeficiência Humana
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article