[Low levels of serotonin in serum correlates with severity of fibromyalgia]. / Bajos valores de serotonina en suero se correlacionan con la gravedad de los síntomas de la fibromialgia.
Med Clin (Barc)
; 135(14): 644-6, 2010 Nov 13.
Article
em Es
| MEDLINE
| ID: mdl-20591450
ABSTRACT
OBJECTIVE:
Fibromyalgia (FM) is a chronic pain syndrome of unknown etiology, which affects predominantly women. Among the alterations that have been implicated in the pathophysiology of FM, there have been postulated disturbances in serotonin levels and metabolism, and their implication in symptoms. The aim of the present study was to assess the correlation levels between low levels of serotonin and severity of symptoms in FM. PATIENTS ANDMETHODS:
We determined serotonin levels using an ELISA kit in serum from 38 FM patients and 25 healthy individual. Results were correlated with symptoms regarding pain, depression, impact of disease (FIQ) and age.RESULTS:
Serotonin levels were decreased by 45% compared to healthy individual. An important correlation was observed between serotonin levels and predetermined parameters of pain, depression, FIQ and age.CONCLUSION:
Serotonin levels are correlated with severity of FM. In addition, there is an interesting correlation between serotonin levels and age of patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Serotonina
/
Fibromialgia
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
Es
Ano de publicação:
2010
Tipo de documento:
Article