Maternal and fetal thrombophilia in intrauterine growth restriction in the presence or absence of maternal hypertensive disease.
Reprod Sci
; 17(9): 844-8, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20601540
ABSTRACT
Intrauterine growth restriction (IUGR) depends on the placental capacity to transfer oxygen and nutrients from the maternal to the fetal circulation. Placental insufficiency may be caused by impairment of the maternal or fetal circulation by a thrombotic event, possibly associated with thrombophilic disorders. The goals of our study were to define the role of maternal/fetal gain-of-function factor V Leiden and prothrombin G20210A mutations in the development of IUGR and to evaluate whether maternal pregnancy-induced hypertensive diseases would modify any such association. This is a case-control study controls were 259 normal pregnancies, cases were 77 IUGR, 28 with and 49 without preeclampsia (PE) or pregnancy-induced hypertension (PIH). An association was found between IUGR and fetal thrombophilia (OR 2.09 CI 95% 1-4.5). The association was stronger in IUGR without PE and PIH (OR 2.9 CI 95% 1.3-6.6). This suggests a role for the fetal genotype in the development of IUGR.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Hematológicas na Gravidez
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Fator V
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Protrombina
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Trombofilia
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Hipertensão Induzida pela Gravidez
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Doenças Fetais
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Retardo do Crescimento Fetal
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Pregnancy
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article