New links between vesicle coats and Rab-mediated vesicle targeting.
Semin Cell Dev Biol
; 22(1): 18-26, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-20643221
ABSTRACT
Vesicle trafficking is a highly regulated process that transports proteins and other cargoes through eukaryotic cells while maintaining cellular organization and compartmental identity. In order for cargo to reach the correct destination, each step of trafficking must impart specificity. During vesicle formation, this is achieved by coat proteins, which selectively incorporate cargo into the nascent vesicle. Classically, vesicle coats are thought to dissociate shortly after budding. However, recent studies suggest that coat proteins can remain on the vesicle en route to their destination, imparting targeting specificity by physically and functionally interacting with Rab-regulated tethering systems. This review focuses on how interactions among Rab GTPases, tethering factors, SNARE proteins, and vesicle coats contribute to vesicle targeting, fusion, and coat dynamics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vesículas Revestidas
/
Proteínas rab de Ligação ao GTP
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article