A surface protein of Streptococcus suis serotype 2 identified by proteomics protects mice against infection.
J Proteomics
; 73(12): 2365-9, 2010 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-20656083
ABSTRACT
Streptococcus suis serotype 2 is a major Gram-positive swine pathogen, causing also zoonoses. We describe here the immunoprotective activity in an in vivo animal model of a serotype-2 cell wall protein, designated Sat, which was identified by a previously validated proteomics approach consisting of the protease digestion of live bacteria and the selective recovery of exposed domains, followed by LC/MS/MS analysis. Increased survival rate (80%) and decreased bacterial burden were observed in mice immunized with a recombinant Sat fragment, suggesting that this protein is a potential vaccine candidate against serotype-2 infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Estreptocócicas
/
Doenças dos Suínos
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Proteínas de Bactérias
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Vacinas Estreptocócicas
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Proteínas de Membrana
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article