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Selective regional perfusion of the bilateral external carotid arteries with pegylated liposomal doxorubicin and melphalan to treat metastatic malignant melanoma of the scalp.
Göppner, D; Quist, S R; Franke, I; Ulrich, J; Drecoll, U; Bürger, T; Gollnick, H P M; Bonnekoh, B.
Afiliação
  • Göppner D; Dermatology and Venerology Clinic, Otto-von-Guericke University, Magdeburg, Germany.
Clin Exp Dermatol ; 36(3): 270-2, 2011 Apr.
Article em En | MEDLINE | ID: mdl-20659118
ABSTRACT
We present the case of a 79-year-old patient with extensive metastatic malignant melanoma (MM) of the scalp. Cutaneous MM of the head and neck often presents a therapeutic challenge. Radical surgical procedures and conventional chemotherapy are often unfeasible and contraindicated because of the difficult anatomy, the extent of the tumour process, and systemic toxicity. In our patient, selective intra-arterial perfusion with pegylated liposomal doxorubicin (PLD) and melphalan was performed after catheterization of both bilateral external carotid arteries with an arterial port system. PLD 4.5 mg/m(2) and melphalan (1.35 mg/m(2), followed by 2.7 mg/m(2) after reaching tolerance) were given as short-term infusions at two-weekly intervals into the right and left external carotid arteries, respectively. After eight applications with tolerable side-effects, no MM cells were detected; however, infiltrates of lymphocytes and melanophages were seen. This case suggests that intra-arterial chemotherapy may be a useful treatment for metastatic melanoma of the scalp.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Couro Cabeludo / Neoplasias Cutâneas / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias de Cabeça e Pescoço / Melanoma Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Couro Cabeludo / Neoplasias Cutâneas / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias de Cabeça e Pescoço / Melanoma Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article