Increase in polysialyltransferase gene expression following LTP in adult rat dentate gyrus.
Hippocampus
; 21(11): 1180-9, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-20665595
ABSTRACT
Neural cell adhesion molecule (NCAM) is frequently associated with polysialic acid (PSA), and its function is highly dependent on this polysialylation. PSA-NCAM plays an important role in synaptic plasticity in the hippocampus. STX and PST are the enzymes responsible for NCAM polysialylation. We investigated whether unilateral long-term potentiation (LTP) induction in vivo, in adult rat dentate gyrus (DG), triggered NCAM polysialylation by STX and PST produced in the hippocampus. We found that levels of STX and PST mRNA increased strongly since the early stage of hippocampal LTP and remained high during the maintenance of DG-LTP for 4 h. This rapid increase in polysialyltransferase gene expression occurred in both the hippocampi, probably resulting from bilateral LTP induction by strong unilateral HFS. Thus, LTP triggers interhemispheric molecular changes in the hippocampal network. This study is the first to describe the effects of LTP induction and maintenance on polysialyl-transferases in vivo. Our findings suggest that hippocampal synaptic remodeling requires NCAM polysialylation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sialiltransferases
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Regulação Enzimológica da Expressão Gênica
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Potenciação de Longa Duração
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Moléculas de Adesão de Célula Nervosa
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Giro Denteado
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article