Sustained viral load and late death in Rag2-/- mice after influenza A virus infection.
Virol J
; 7: 172, 2010 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-20667098
ABSTRACT
The importance of the adaptive immune response for secondary influenza infections and protection from a lethal challenge after vaccination has been well documented. However, some controversy still exists concerning the specific involvement of B and T cells during a primary infection. Here, we have followed the survival, weight loss, viral load and lung pathology in Rag2-/- knock-out mice after infection with influenza A virus (H1N1). Infected wild type mice initially lost weight early after infection but then cleared the virus and recovered. Rag2-/- mice, however, showed similar weight loss kinetics in the early stages after infection but weight loss continued post infection and culminated in death. In contrast to wild type mice, Rag2-/- mice were not able to clear the virus, despite an increased inflammatory response. Furthermore, they did not recruit virus-specific lymphocytes into the lung in the later stages after infection and exhibited sustained pulmonary lesions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carga Viral
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Proteínas de Ligação a DNA
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Influenza Humana
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Vírus da Influenza A Subtipo H1N1
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article