Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 66(Pt 8): 964-8, 2010 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-20693682
ABSTRACT
An antibody Fab fragment, AbD1556, was selected against the extracellular domain of BMP receptor type IA, which blocks the binding of BMP-2 to BMPR-IA and thereby neutralizes BMP-2 activity. To study the mechanism by which BMPR-IA is recognized and bound by the Fab fragment, the complex of AbD1556 bound to BMPR-IA was prepared and crystallized. Crystals of this binary complex belonged to the monoclinic space group P2(1), with unit-cell parameters a=89.32, b=129.25, c=100.24 A, beta=92.27 degrees.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragmentos Fab das Imunoglobulinas
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Receptores de Proteínas Morfogenéticas Ósseas Tipo I
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Complexo Antígeno-Anticorpo
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article