Blood lead at currently acceptable levels may cause preterm labour.
Occup Environ Med
; 68(3): 231-4, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-20798002
ABSTRACT
OBJECTIVES:
Although occupational and environmental exposures to lead have been dramatically reduced in recent decades, adverse pregnancy outcomes have been observed at 'acceptable' levels of blood lead concentrations (≤ 10 µg/dl).METHODOLOGY:
Blood samples were collected from 348 singleton pregnant women, aged 16-35 years, during the first trimester of pregnancy (8-12 weeks) for lead measurement by inductively coupled plasma-mass spectrometry. Subjects were followed up and divided into two groups (preterm and full-term deliveries) according to duration of gestation.RESULTS:
The average (range) and geometric means of blood lead levels were 3.8 (1.0-20.5) and 3.5 µg/dl, respectively. Blood lead level was significantly (p<0.05) higher in mothers who delivered preterm babies than in those who delivered full-term babies (mean±SD 4.46±1.86 and 3.43±1.22 µg/dl, respectively). Logistic regression analysis demonstrated that a 1 unit increase in blood lead levels led to an increased risk of preterm birth (OR 1.41, 95% CI 1.08 to 1.84).CONCLUSION:
Adverse pregnancy outcomes may occur at blood lead concentrations below the current acceptable level.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trabalho de Parto Prematuro
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Chumbo
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article