AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation.
Proc Natl Acad Sci U S A
; 107(36): 15975-80, 2010 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-20798031
ABSTRACT
Spike timing-dependent long-term potentiation (t-LTP) is the embodiment of Donald Hebb's postulated rule for associative memory formation. Pre- and postsynaptic action potentials need to be precisely correlated in time to induce this form of synaptic plasticity. NMDA receptors have been proposed to detect correlated activity and to trigger synaptic plasticity. However, the slow kinetic of NMDA receptor currents is at odds with the millisecond precision of coincidence detection. Here we show that AMPA receptors are responsible for the extremely narrow time window for t-LTP induction. Furthermore, we visualized synergistic interactions between AMPA and NMDA receptors and back-propagating action potentials on the level of individual spines. Supralinear calcium signals were observed for spike timings that induced t-LTP and were most pronounced in spines well isolated from the dendrite. We conclude that AMPA receptors gate the induction of associative synaptic plasticity by regulating the temporal precision of coincidence detection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Cálcio
/
Receptores de AMPA
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article