Cognitive function in type 1 diabetic adults with early exposure to severe hypoglycemia: a 16-year follow-up study.
Diabetes Care
; 33(9): 1945-7, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20805272
ABSTRACT
OBJECTIVE:
We assessed adulthood cognition in relation to early exposure to severe hypoglycemia (SH). RESEARCH DESIGN ANDMETHODS:
Sixteen years subsequent to a study of cognitive function in 28 diabetic children and 28 matched control subjects, we reexamined the same subjects with a 96% participation rate. Diabetic subjects were classified as with (n = 9) or without (n = 18) early (RESULTS:
Overall, cognitive scores were 0.9 SDs lower in subjects with early SH compared with subjects without early SH (P = 0.003). The two diabetic groups particularly differed with respect to problem solving, verbal function, and psychomotor efficiency. Earlier age at first incident of SH was associated with poorer cognition (P for trend = 0.001).CONCLUSIONS:
The findings suggest that early exposure to SH may have lasting and clinically relevant effects on cognition.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cognição
/
Diabetes Mellitus Tipo 1
/
Hipoglicemia
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article