Multimodal tumor-targeting peptides functionalized with both a radio- and a fluorescent label.
Bioconjug Chem
; 21(10): 1709-19, 2010 Oct 20.
Article
em En
| MEDLINE
| ID: mdl-20812730
ABSTRACT
The use of monolabeled tumor-targeting peptides for molecular imaging is widespread. However, it is often desirable to use the same compound for different clinical applications, e.g., combined pre- and intraoperative tumor detection. On the basis of their detection sensitivity, the combination of radioactivity and fluorescence is probably the most valuable in multimodal molecular imaging. In this review, we compare multimodal peptide derivatives and discuss the influence of the diagnostic labels on receptor affinity and biodistribution. On the basis of the described constructs, we propose improvements for the design of future multimodal tumor-targeting peptide derivatives.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Imagem Molecular
/
Corantes Fluorescentes
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article