Cyclic adenosine monophosphate induces plasminogen activator inhibitor-1 expression in human mast cells.
Biochem Biophys Res Commun
; 400(4): 569-74, 2010 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-20816667
ABSTRACT
Plaminogen activator inhibitor-1 (PAI-1), the key physiological inhibitor of the plasmin fibrinolytic system, plays important roles in the pathogenesis of asthma. Mast cells (MCs) are crucial effector cells and a major source of PAI-1 for asthma. Cyclic adenosine monophosphate (cAMP) is the important regulator of MCs; however, its effects on PAI-1 expression in MCs remain unknown. We reported cAMP/protein kinase A pathway positively regulates PAI-1 expression through cAMP-response element binding protein binding to hypoxia response element-1 at -158 to -153bp of human PAI-1 promoter in human MCs. Moreover, cAMP synergistically augments PAI-1 expression with ionomycin- or IgE receptor cross-linking-mediated stimulation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Regulação da Expressão Gênica
/
Inibidor 1 de Ativador de Plasminogênio
/
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico
/
AMP Cíclico
/
Mastócitos
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article