Triclosan has endocrine-disrupting effects in male western mosquitofish, Gambusia affinis.
Environ Toxicol Chem
; 29(6): 1287-91, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20821571
ABSTRACT
Triclosan (TCS) is an antibacterial agent used in a variety of personal care and industrial products. Triclosan and its environmentally transformed derivative, methyl-TCS, have been detected in waters receiving effluent from public wastewater treatment plants. Previous studies have demonstrated that TCS has the potential to act as an endocrine disruptor. The present study tested the hypothesis that TCS acts as an endocrine-disrupting agent in fish. Mature male western mosquitofish, Gambusia affinis, were exposed to TCS concentrations of 100, 200, and 350 nM (29.0, 57.9, and 101.3 microg/L) for 35 d by the static renewal method. Induction of the normally female-limited vitellogenin gene expression and reduction in sperm count were quantified as biomarkers of endocrine disruption. Vitellogenin mRNA expression was significantly elevated in the 350 nM TCS treatment. Sperm counts in the same treatment group were significantly decreased. The mean hepatosomatic index in the 350 nM treatment group was significantly increased. This study demonstrates that TCS has the potential to act as an endocrine disruptor in male mosquitofish.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Espermatogênese
/
Triclosan
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Poluentes Químicos da Água
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Eliminação de Resíduos Líquidos
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Disruptores Endócrinos
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Peixes
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article