Spatial correlation between brain aerobic glycolysis and amyloid-ß (Aß ) deposition.
Proc Natl Acad Sci U S A
; 107(41): 17763-7, 2010 Oct 12.
Article
em En
| MEDLINE
| ID: mdl-20837517
ABSTRACT
Amyloid-ß (Aß) plaque deposition can precede the clinical manifestations of dementia of the Alzheimer type (DAT) by many years and can be associated with changes in brain metabolism. Both the Aß plaque deposition and the changes in metabolism appear to be concentrated in the brain's default-mode network. In contrast to prior studies of brain metabolism which viewed brain metabolism from a unitary perspective that equated glucose utilization with oxygen consumption, we here report on regional glucose use apart from that entering oxidative phosphorylation (so-called "aerobic glycolysis"). Using PET, we found that the spatial distribution of aerobic glycolysis in normal young adults correlates spatially with Aß deposition in individuals with DAT and cognitively normal participants with elevated Aß, suggesting a possible link between regional aerobic glycolysis in young adulthood and later development of Alzheimer pathology.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
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Encéfalo
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Doença de Alzheimer
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Glucose
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Amiloide
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article