Adenovirus 36 and obesity in children and adolescents.
Pediatrics
; 126(4): 721-6, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20855385
ABSTRACT
OBJECTIVE:
The primary aim of this study was to assess the relationship between adenovirus 36 (AD36)-specific antibodies and obesity in children.METHODS:
A cross-sectional study of children 8 to 18 years of age was performed. Children were classified according to BMI percentile as nonobese (<95th percentile) or obese (≥95th percentile). The presence of AD36-specific neutralizing antibodies was assessed by using the serum neutralization assay.RESULTS:
A total of 124 children (median age 13.6 years) were studied. Of those children, 46% were nonobese and 54% were obese. AD36 positivity was present in 19 children (15%). The majority of children found to be AD36-positive were obese (15 [78%] of 19 children). AD36 positivity was significantly (P<.05) more frequent in obese children (15 [22%] of 67 children) than nonobese children (4 [7%] of 57 children). Among the subset of children who were obese, those who were AD36-positive had significantly larger anthropometric measures, including weight, BMI, waist circumference, and waist/height ratio.CONCLUSION:
These data support an association of obesity and higher body weight with the presence of neutralizing antibodies to AD36 in children. If a cause-and-effect relationship is established, it would have considerable implications for the prevention and treatment of childhood obesity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adenovírus Humanos
/
Anticorpos Neutralizantes
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Anticorpos Antivirais
/
Obesidade
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article