Anorectal Epstein-Barr virus infection mimicking Hodgkin lymphoma in an immunocompetent man.
Am J Surg Pathol
; 34(11): 1715-9, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-20861713
ABSTRACT
Anorectal Hodgkin lymphoma (HL) is rare, mainly described in human immunodeficiency virus (HIV) patients with exceptional cases reported in immunocompetents. We report the case of a middle age HIV male, presenting with intestinal occlusion. Rectosigmoidoscopy showed multiple anorectal nodular and ulceronecrotic masses. The biopsy specimens revealed a diffuse polymorphous inflammatory infiltrate in the lamina propria, associated with CD30, CD20, CD3, CD15, and ALK1 scattered large Hodgkin and/or Reed Sternberg -like cells stained by LMP1 antibody and EBER. A diagnosis of EBV-associated atypical lymphoproliferative disease mimicking HL was made. These lesions remained stable for 2 years without treatment then disappeared leaving a mucosal scar. A later control biopsy showed a condylomatous lesion, without lymphoid lesion, suggesting a sexually acquired infection. Eight years later, the complete resolution of the lesion without any treatment is a strong argument against a malignant lymphoid process and raises doubts as to the reality of isolated anorectal HL in immunocompetent participants.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças do Ânus
/
Doenças Retais
/
Doença de Hodgkin
/
Doenças Virais Sexualmente Transmissíveis
/
Infecções por Vírus Epstein-Barr
/
Imunocompetência
/
Transtornos Linfoproliferativos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article