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Evolutionary mechanism as a template for protein engineering.
Eisenbeis, Simone; Höcker, Birte.
Afiliação
  • Eisenbeis S; Max Planck Institute for Developmental Biology, Tübingen, Germany.
J Pept Sci ; 16(10): 538-44, 2010 Oct.
Article em En | MEDLINE | ID: mdl-20862721
ABSTRACT
The goal of a protein engineer is to adjust a protein to a specified new function. This is exactly what natural evolution has achieved many times. By studying evolutionary mechanisms, we can learn about ways to use the adaptability of proteins and to build new proteins. In fact, many techniques used in engineering are successfully mimicking evolutionary processes. We introduce the fundamental evolutionary mechanisms, take a closer look at duplication and fusion, recombination, and circular permutation and discuss their influence on protein engineering. Some important techniques are presented and illustrated with examples.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Proteínas / Evolução Molecular Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Proteínas / Evolução Molecular Idioma: En Ano de publicação: 2010 Tipo de documento: Article