Grape-seed polyphenolic extract improves the eye phenotype in a Drosophila model of tauopathy.
Int J Alzheimers Dis
; 20102010 Aug 24.
Article
em En
| MEDLINE
| ID: mdl-20871666
ABSTRACT
Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/aggregation suggest that GSPE may have therapeutic value in disorders involving aberrant protein aggregation.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article