Treatment of primary CNS lymphoma with high-dose methotrexate in immunocompetent pediatric patients.
Pediatr Blood Cancer
; 55(6): 1227-30, 2010 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-20882580
ABSTRACT
We report two cases of primary CNS lymphoma (PCNSL) treated with high-dose methotrexate. Though standard adult treatment of PCNSL incorporates whole-brain radiotherapy, the literature suggests it may be possible to delay or avoid radiotherapy and the associated increased risk of neurologic sequelae in pediatric patients. Studies in adults indicate methotrexate therapy can be effective against PCNSL and has advantages over the current standard of treatment. Both patients have no evidence of disease 9 and 7 years after treatment, suggesting high-dose methotrexate may lead to disease control in pediatric patients with PCNSL while avoiding the effects of radiotherapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Metotrexato
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Linfoma de Células B
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Neoplasias do Sistema Nervoso Central
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Linfoma Anaplásico de Células Grandes
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Antimetabólitos Antineoplásicos
Limite:
Adolescent
/
Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article