A new series of antiarrhythmic procainamide derivatives: toxicity and activity-simulated passive absorption relation.
Farmaco
; 45(12): 1351-9, 1990 Dec.
Article
em En
| MEDLINE
| ID: mdl-2090144
ABSTRACT
Several compounds derived from benzamidines and nicotinic pyridinic amidines with a structure similar to that of procainamide, exhibit notable antiarrhythmic properties after injection into animals. The diffusion rate of these different compounds through a solid lipidic artificial membrane was studied with Dibbern's apparatus. A statistical relation was established between the diffusion rate and the principal pharmacological parameters obtained after intraperitoneal injection (toxicity and anthiarrhythmic activity). Essential structural elements seem to determine a better bioavailability than procainamide character of the substitution (in para) of the benzenic cycle; length of the lateral chain.
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Base de dados:
MEDLINE
Assunto principal:
Procainamida
/
Antiarrítmicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article