A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia.
Blood
; 117(1): 242-5, 2011 Jan 06.
Article
em En
| MEDLINE
| ID: mdl-20935257
ABSTRACT
Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative genomic hybridization array as the retinoid acid receptor gamma gene (RARG). The involvement of RARG in a chimeric fusion transcript has not been reported previously in human leukemia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
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Leucemia Promielocítica Aguda
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Proteínas de Fusão Oncogênica
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Receptores do Ácido Retinoico
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Complexo de Proteínas Formadoras de Poros Nucleares
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Fusão Gênica
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
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Humans
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Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article