Inhibition of bacterial multidrug resistance by celecoxib, a cyclooxygenase-2 inhibitor.
Antimicrob Agents Chemother
; 55(1): 439-42, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-20937780
ABSTRACT
Multidrug resistance (MDR) is a major problem in the treatment of infectious diseases and cancer. Accumulating evidence suggests that the cyclooxygenase-2 (COX-2)-specific inhibitor celecoxib would not only inhibit COX-2 but also help in the reversal of drug resistance in cancers by inhibiting the MDR1 efflux pump. Here, we demonstrate that celecoxib increases the sensitivity of bacteria to the antibiotics ampicillin, kanamycin, chloramphenicol, and ciprofloxacin by accumulating the drugs inside the cell, thus reversing MDR in bacteria.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Sulfonamidas
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Farmacorresistência Bacteriana Múltipla
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Inibidores de Ciclo-Oxigenase 2
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article