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Extension of the lifespan of Caenorhabditis elegans by the use of electrolyzed reduced water.
Yan, Hanxu; Tian, Huaize; Kinjo, Tomoya; Hamasaki, Takeki; Tomimatsu, Kosuke; Nakamichi, Noboru; Teruya, Kiichiro; Kabayama, Shigeru; Shirahata, Sanetaka.
Afiliação
  • Yan H; Graduate School of Systems Life Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
Biosci Biotechnol Biochem ; 74(10): 2011-5, 2010.
Article em En | MEDLINE | ID: mdl-20944427
Electrolyzed reduced water (ERW) has attracted much attention because of its therapeutic effects. In the present study, a new culture medium, which we designated Water medium, was developed to elucidate the effects of ERW on the lifespan of Caenorhabditis elegans. Wild-type C. elegans had a significantly shorter lifespan in Water medium than in conventional S medium. However, worms cultured in ERW-Water medium exhibited a significantly extended lifespan (from 11% to 41%) compared with worms cultured in ultrapure water-Water medium. There was no difference between the lifespans of worms cultured in ERW-S medium and ultrapure water-S medium. Nematodes cultured in ultrapure water-Water medium showed significantly higher levels of reactive oxygen species than those cultured in ultrapure water-S medium. Moreover, ERW-Water medium significantly reduced the ROS accumulation induced in the worms by paraquat, suggesting that ERW-Water medium extends the longevity of nematodes at least partly by scavenging ROS.
Assuntos
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Base de dados: MEDLINE Assunto principal: Água / Caenorhabditis elegans / Eletrólise / Longevidade Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Água / Caenorhabditis elegans / Eletrólise / Longevidade Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article