High prevalence of drug-resistant tuberculosis and other mycobacteria among HIV-infected patients in Brazil: a systematic review.
Mem Inst Oswaldo Cruz
; 105(6): 838-41, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20945003
ABSTRACT
There is a little-noticed trend involving human immunodeficiency virus (HIV)-infected patients suspected of having tuberculosis the triple-treatment regimen recommended in Brazil for years has been potentially ineffective in over 30% of the cases. This proportion may be attributable to drug resistance (to at least 1 drug) and/or to infection with non-tuberculous mycobacteria. This evidence was not disclosed in official statistics, but arose from a systematic review of a few regional studies in which the diagnosis was reliably confirmed by mycobacterial culture. This paper clarifies that there has long been ample evidence for the potential benefits of a four-drug regimen for co-infected patients in Brazil and it reinforces the need for determining the species and drug susceptibility in all positive cultures from HIV-positive patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Oportunistas Relacionadas com a AIDS
/
Tuberculose Resistente a Múltiplos Medicamentos
/
Infecções por Mycobacterium não Tuberculosas
/
Antituberculosos
Tipo de estudo:
Prevalence_studies
/
Systematic_reviews
Limite:
Humans
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article