Nickel chloride effects on erythrocyte generation of superoxide radical.
Braz J Med Biol Res
; 23(8): 643-5, 1990.
Article
em En
| MEDLINE
| ID: mdl-2101086
ABSTRACT
The superoxide anion (O2-) is an extremely potent free radical which is produced during the metabolism of aerobic living cells. (O2-) may be involved in lipid peroxidation reactions which occur in a variety of systems. Cu-Zn superoxide dismutase, a metalloprotein, catalyzes the dismutation of the superoxide free radical and protects cells against superoxide damage. The ability of NiCl2 to prevent lysis of erythrocytes was tested in rats. NiCl2 administered by intratracheal route prevented hemolysis and decreased total lipids, phospholipids and bilirubin in serum. The protective effect of NiCl2 was linked to an increase in the erythrocyte activity of superoxide dismutase.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
/
Eritrócitos
/
Níquel
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article