Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria.
J Nat Prod
; 73(11): 1922-6, 2010 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-21028889
ABSTRACT
The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca(2+) flux. These compounds include known thiazoline compounds and a series of new derivatives, pulicatins A-E (6-10). Individual compounds were shown to bind to a series of human receptors, with selective binding to the human serotonin 5-HT(2B) receptor. Here, we report the structure elucidation of the new compounds and results of the neurological assays.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Caramujo Conus
/
Tiazolidinas
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article