SmI2-mediated radical cyclizations directed by a C-Si bond.
Org Lett
; 12(23): 5446-9, 2010 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-21049913
ABSTRACT
The use of a silicon stereocontrol element in cyclobutanol and cyclopentanol-forming cyclizations mediated by SmI(2) results in excellent diastereocontrol. The C-Si bond in the products of cyclization provides a versatile handle for further manipulation. An asymmetric route to cyclization substrates involving copper-catalyzed silyl transfer has also been developed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Samário
/
Silício
/
Carbono
/
Iodetos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article