Septic-associated encephalopathy--everything starts at a microlevel.
Crit Care
; 14(5): 199, 2010.
Article
em En
| MEDLINE
| ID: mdl-21067627
ABSTRACT
Sepsis-associated encephalopathy is associated with increased mortality and morbidity. Its pathophysiology remains insufficiently elucidated, although there is evidence for a neuroinflammatory process sequentially involving endothelial activation, blood-brain barrier alteration and cellular dysfunction and alteration in neurotransmission. Experimental studies have shown that microcirculatory dysfunction, a consequence of endothelial activation, is an early pathogenic step. To date, we do not know whether it is present in septic patients, whether it accounts for clinical features and whether it is treatable.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Encefalite
/
Microcirculação
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article